Cholesterol in brain disease: sometimes determinant and frequently implicated
نویسندگان
چکیده
منابع مشابه
Cholesterol in brain disease: sometimes determinant and frequently implicated.
Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, cell shape, cell-cell interaction, and transmembrane signaling. Consistently, hereditary diseases with mutations in cholesterol-related genes result in impaired brain funct...
متن کاملConvergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis.
Polymorphic genes associated with Alzheimer's disease (see ) delineate a clearly defined pathway related to cerebral and peripheral cholesterol and lipoprotein homoeostasis. They include all of the key components of a glia/neurone cholesterol shuttle including cholesterol binding lipoproteins APOA1, APOA4, APOC1, APOC2, APOC3, APOD, APOE and LPA, cholesterol transporters ABCA1, ABCA2, lipoprote...
متن کاملParkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis
Substantial evidence implicates abnormal protein kinase function in various aspects of Parkinson's disease (PD) etiology. Elevated phosphorylation of the PD-defining pathological protein, α-synuclein, correlates with its aggregation and toxic accumulation in neurons, whilst genetic missense mutations in the kinases PTEN-induced putative kinase 1 and leucine-rich repeat kinase 2, increase suscep...
متن کاملProtein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance
In the hierarchy of cellular targets damaged by ionizing radiation (IR), classical models of radiation toxicity place DNA at the top. Yet, many prokaryotes are killed by doses of IR that cause little DNA damage. Here we have probed the nature of Mn-facilitated IR resistance in Deinococcus radiodurans, which together with other extremely IR-resistant bacteria have high intracellular Mn/Fe concen...
متن کاملBrain-stem microRNAs implicated in hypertension.
BRAIN-STEM NUCLEI PLAY A CRUCIAL role in the regulation of blood pressure (BP) and other cardiovascular functions (2, 4). Defect(s) in central neural mechanisms that control sympathetic outflow have been suggested to be involved, in part, in the onset and maintenance of the elevated BP in hypertension. It is well known that hypertension involves a genetic predisposition. Since the genetic “defe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EMBO reports
سال: 2014
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201439225